PERMEATION STUDY OF CARROT EXTRACT EMULGEL (DAUCUS CAROTA L.)

Abstract

A permeation study, also known as a penetration or drug absorption test, is a key method for assessing how a topical preparation is absorbed into the skin. Using a Franz diffusion cell, this study models how a topical formulation penetrates and is absorbed by the skin, simulating actual skin conditions, including pH, physiological fluids, temperature, and pore size. This research focused on conducting a permeation study for emulgel preparations containing vitamin C, valued for its antioxidant properties. The study measured two main values: the cumulative penetration amount of carrot root extract (Daucus carota L.) in the emulgel, and the flux of carrot extract in each sample. Among the three samples tested, Sample 1 demonstrated the highest cumulative penetration of active ingredients, reaching 12,789.08 ± 83.44 µg/cm², and achieved the highest flux value at 60.34 ± 0.23 µg/cm²/min. These findings highlight Sample 1's superior effectiveness in delivering the carrot root extract’s antioxidant benefits through the emulgel formulation.