PERMEATION STUDY OF VITAMIN C EMULGEL WITH VARIATIONS IN GELLING AGENT CONTENT

Abstract

A permeation study, also known as a penetration test or drug absorption test, is used to evaluate the absorption of a topical preparation into the skin. This is typically conducted using a Franz diffusion cell, a simulation model that mimics how a topical preparation penetrates or is absorbed by the skin. The device is designed to replicate actual skin conditions, including pH, physiological fluids, temperature, and pore size. The aim of this research is to demonstrate how permeation studies are conducted on topical preparations, specifically emulgel formulations containing vitamin C, which serves as an antioxidant. In this study, the key values measured include the cumulative penetration of vitamin C into the emulgel and the flux value of vitamin C from each sample. The results from three samples indicate that Sample 1 exhibited the highest cumulative amount of vitamin C penetration, with a value of 12,789.08 ± 83.44 µg/cm², and the highest flux value, measured at 60.34 ± 0.23 µg/cm².min⁻¹.